Biomarker List

We are pleased to offer an extensive range of biomarker assays to support pharmacodynamic requirements. 

This might be a protein marker, RNA markers, transcriptional analysis (individual or RNA seq by NGS) or small molecules.

We are always pleased to help with biomarker choice and literature evaluation – many biomarkers are of great experimental value but far from validated for use in the clinic – please see our pages on reference ranges and validation for comments which we hope you will find useful.

If the biomarker you require is not listed below, please let us know your requirements. 

Please be aware that several of the genes coding for these bio-markers have significant population dependent polymorphisms. This is rarely taken into account in small scale (Phase I and Phase II) trials, but this can have a significant effect on biomarker data.   We can offer genotyping assays for these polymorphisms and urge you to discuss this with us as part of your PD requirement.

A

Albumin Urine

Antideoxyribonuclease-B (ADN-B)

Antimicrobial Peptides

Apo A-I

Apo B

Apo C2

Apo C3

Apo E

Argininosuccinate lyase (ASL)

B

Beta Quantitation

Blood Urea Nitrogen

C

C Reactive Protein

C3c

C4

Carbohydrate Lipid Parameters (LDL, VLDL)

Carbohydrate Deficient Transferrin

Cholesterol

Creatinine

Creatinine Kinase

Cystatin C

Cystatin C Serum

D

Diagnostic Panel (12) ALP, ALT, AST, TB, GLU, BUN

E

eGFR (Calculated)

Electrolyte Assays – Na, K, Cl, Ca, PHOS, Mg, tCO2

F

FGF-21

Fibrinogen

FLC Kappa

FLC Kappa Urine

FLC Lambda

FLC Lambda Urine

G

GDF-15

Glutathione-S-transferase (GST)

GST/Creatinine ratio

H

HDL-Cholesterol

Hepatocyte Growth Factor

High-Sensitivity CRP

Homocysteine

I

Ig/Light Chain, type kappa

Ig/Light Chain, type kappa urine 4

Ig/Light Chain, type lambda

Ig/Light Chain, type lambda urine 4

IgA

IgE

IgG

IgG urine

IgM

Interleukins, e.g. IL6, IL8

IgM

L

Lactate

Liver Panel (7) ALP, ALT, AST, TP, ALB, TBIL, AMY, GLOB, A/G, B/C

M

microRNA

MMPs / TIMPs

Myeloperoxidase

Myoglobin

N

Neurofilament

Neurogranin

NGAL

Neurogranin

P

Plasminogen activator inhibitor -1

Preanaesthetic Panel (7) – ALP, ALT, TP, ALB, GLU, BUN, CREA, GLOB, A/G, B/C

Pyruvate

R

Rheumatoid Factor (RF)

S

sCD40

Serum Amyloid

T

Tau (including phospho Tau)

Transferrin (for %CDT calculation)

Transferrin Urine

Triglyceride

Tumour Necrosis Factor Alpha

Transferrin Urine

α

α1-Acid Glycoprotein

α1-Microglobulin urine

α2-Macroglobulin urine 4

ß

β2-Microglobulin

β2-Microglobulin urine

β-trace protein

Bespoke assays

We have facilities expertise for method development and validation if you need new asays or want to save money on bought in consumables such as new ELISA based procedures – antibody levels in blood, for example.