We are pleased to offer an extensive range of biomarker assays to support pharmacodynamic requirements.
This might be a protein marker, RNA markers, transcriptional analysis (individual or RNA seq by NGS) or small molecules.
We are always pleased to help with biomarker choice and literature evaluation – many biomarkers are of great experimental value but far from validated for use in the clinic – please see our pages on reference ranges and validation for comments which we hope you will find useful.
If the biomarker you require is not listed below, please let us know your requirements.
Please be aware that several of the genes coding for these bio-markers have significant population dependent polymorphisms. This is rarely taken into account in small scale (Phase I and Phase II) trials, but this can have a significant effect on biomarker data. We can offer genotyping assays for these polymorphisms and urge you to discuss this with us as part of your PD requirement.
A
Albumin Urine
Antideoxyribonuclease-B (ADN-B)
Antimicrobial Peptides
Apo A-I
Apo B
Apo C2
Apo C3
Apo E
Argininosuccinate lyase (ASL)
B
Beta Quantitation
Blood Urea Nitrogen
C
C Reactive Protein
C3c
C4
Carbohydrate Lipid Parameters (LDL, VLDL)
Carbohydrate Deficient Transferrin
Cholesterol
Creatinine
Creatinine Kinase
Cystatin C
Cystatin C Serum
D
Diagnostic Panel (12) ALP, ALT, AST, TB, GLU, BUN
E
eGFR (Calculated)
Electrolyte Assays – Na, K, Cl, Ca, PHOS, Mg, tCO2
F
FGF-21
Fibrinogen
FLC Kappa
FLC Kappa Urine
FLC Lambda
FLC Lambda Urine
G
GDF-15
Glutathione-S-transferase (GST)
GST/Creatinine ratio
H
HDL-Cholesterol
Hepatocyte Growth Factor
High-Sensitivity CRP
Homocysteine
I
Ig/Light Chain, type kappa
Ig/Light Chain, type kappa urine 4
Ig/Light Chain, type lambda
Ig/Light Chain, type lambda urine 4
IgA
IgE
IgG
IgG urine
IgM
Interleukins, e.g. IL6, IL8
IgM
L
Lactate
Liver Panel (7) ALP, ALT, AST, TP, ALB, TBIL, AMY, GLOB, A/G, B/C
M
microRNA
MMPs / TIMPs
Myeloperoxidase
Myoglobin
N
Neurofilament
Neurogranin
NGAL
Neurogranin
P
Plasminogen activator inhibitor -1
Preanaesthetic Panel (7) – ALP, ALT, TP, ALB, GLU, BUN, CREA, GLOB, A/G, B/C
Pyruvate
R
Rheumatoid Factor (RF)
S
sCD40
Serum Amyloid
T
Tau (including phospho Tau)
Transferrin (for %CDT calculation)
Transferrin Urine
Triglyceride
Tumour Necrosis Factor Alpha
Transferrin Urine
α
α1-Acid Glycoprotein
α1-Microglobulin urine
α2-Macroglobulin urine 4
ß
β2-Microglobulin
β2-Microglobulin urine
β-trace protein
Bespoke assays
We have facilities expertise for method development and validation if you need new asays or want to save money on bought in consumables such as new ELISA based procedures – antibody levels in blood, for example.